Testing for statistical equivalence reverses the null hypothesis and test if two treatments are statistically equivalent with a null hypothesis that the treatments are not equivalent . Testing statistical hypotheses of equivalence and noninferiority 2nd edition stefan wellek 2010 isbn 978 1439808184 431 pages 10995 chapman hall crc http . There are several statistical procedures for testing the hypothesis of equivalence eg wellek 2002 in contrast to the classical approach of testing the significance of differences testing . Where z 075 is the 975th percentile of a standard normal distribution note z 0025 z 0975hypotheses assess the mean difference of the test and reference products based on sigma rm r2 the variability of the super distribution of reference genotype meansvahl kang reference vahl and kang 2015 referred to it as addressing super equivalence